Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats
Identifieur interne : 004035 ( Main/Exploration ); précédent : 004034; suivant : 004036Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats
Auteurs : Elena I. Miklyaeva [Canada] ; David J. Martens [Canada] ; Ian Q. Whishaw [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1995.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animal model, Animals, Behavior, Animal (physiology), Body movement, Brain Chemistry (drug effects), Brain Chemistry (physiology), Compensation, Depletion, Dopamine, Dopamine (physiology), Dopamine and behavioral compensation, Dopamine and locomotion, Dopamine and turning, Dopamine and turning in rat, Dopamine and voluntary movement, Feeding Behavior (physiology), Female, Functional Laterality (physiology), Gait (physiology), Grooming (physiology), Locomotion, Locomotion (physiology), Movement (physiology), Oxidopamine (pharmacology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (psychology), Parkinson disease, Parkinson's disease model, Posture, Rat, Rats, Videotape Recording.
- MESH :
- chemical , pharmacology : Oxidopamine.
- chemical , physiology : Dopamine.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Brain Chemistry.
- physiology : Behavior, Animal, Brain Chemistry, Feeding Behavior, Functional Laterality, Gait, Grooming, Locomotion, Movement.
- psychology : Parkinson Disease, Secondary.
- Animals, Female, Posture, Rats, Videotape Recording.
Abstract
Abstract: Rats with unilateral domapine (DA) depletions (hemi-Parkinson rats) display directional biases in their locomotion in spontaneous and drug induced tests. These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine.
Url:
DOI: 10.1016/0006-8993(95)00277-W
Affiliations:
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Le document en format XML
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These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Miklyaeva, Elena I" sort="Miklyaeva, Elena I" uniqKey="Miklyaeva E" first="Elena I." last="Miklyaeva">Elena I. Miklyaeva</name></noRegion><name sortKey="Martens, David J" sort="Martens, David J" uniqKey="Martens D" first="David J." last="Martens">David J. Martens</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. 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